I did the following and have very little spam issues:
- Use all elements the "Spam Be Gone" plugin offers: Askimet post check, Honeypot registration, Re-Captcha (v2) for registration, Stopformspam post check. All at default settings at the moment
- Disabled "About me" and "Signature" profile elements as the "Spam Be Gone" plugin does not check these
- Beep plugin to censor prohibited words on legitimate posts / topics
So far I have not had to use the post or registration queue. Not popular enough yet I guess, so the "Spam Be Gone" plugin suffices for now. I am very grateful for the anti spam tool-suite, which do work great. I know for a fact we would be riddled with spam without it.