Thanks for the reply, I spend few hours looking into it, and the solutions was this simple. Thanks.

I have the same issue, here is what Im using
Ubuntu 16.04,
nginx/1.10.0
node v6.9.4

Config files:

server {
    listen 80;
    listen [::]:80;
    server_name minnotes.mzlabs.net;

    location / {
        proxy_set_header X-Real-IP $remote_addr;
        proxy_set_header X-Forwarded-For $proxy_add_x_forwarded_for;
        proxy_set_header X-Forwarded-Proto $scheme;
        proxy_set_header Host $http_host;
        proxy_set_header X-NginX-Proxy true;
        proxy_pass http://localhost:4567;
        proxy_redirect off;
        # Socket.IO Support
        proxy_http_version 1.1;
        proxy_set_header Upgrade $http_upgrade;
        proxy_set_header Connection "upgrade";
    }
}

For Config file im using

{
    "url": "http://localhost:4567",
    "secret": "7ab49b85-e...",
    "database": "redis",
    "redis": {
            "host": "127.0.0.1",
            "port": "6379",
            "password": "...",
            "database": "1"
    }
}

Also when I start it using node app.js, one of the lines says:

 14/3 15:11:55 [12013] - info: [socket.io] Restricting access to origin: http://localhost:*

Error i getting

2017/03/14 15:18:19 [error] 1416#1416: *89 connect() failed (111: Connection refused) while connecting to upstream, client: 50.23.111.246, server: minnotes.mzlabs.net, request: "GET /socket.io/?EIO=3&transport=polling&t=LhDPWjZ HTTP/1.1", upstream: "http://[::1]:4567/socket.io/?EIO=3&transport=polling&t=LhDPWjZ", host: "minnotes.mzlabs.net", referrer: "http://minnotes.mzlabs.net/"

Any ideas?