Yup, we run our NodeBB forum out of EC2. The trickiest setup was Redis, but here are a couple links which helped:
I'm interested in investigating Redis on ElastiCache, but haven't had the time yet.
Other than that, you'll need to install Node.js, of course. It's pretty straight forward (git clone the repo and build/install), but I think you may need to add some directories to PATH or other small setup tweaks. There are a probably a bunch of guides if you Google around.